The first settlers of the Village of Tangipahoa traveled to the area by wagon train in 1806. Arriving from South Carolina were Mrs. Rhoda Holly Singleton Mixon and her daughter, Martha Singleton. Mrs. Mixon purchased about six sections of land now comprising the site of the Village of Tangipahoa and vicinity. In the year 1854, the I.C. Railroad was completed from New Orleans to Jackson, Mississippi. The Village was later incorporated and according to the 1995 census, had 624 residents.