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From the Louisiana Side: To reach the southern tip of the refuge, take I-59 to Pearl River Turnaround Exit 11. Heading east from this exit takes you to a fishing area, turning west will take you toward the Holmes Bayou Trail. The Refuge can also be accessed from Locks 1, 2, & 3 by taking Hwy. 41 N. of Slidell. Mississippi Side: To reach the furthermost E. side of the Refuge, take I-59 N. to Picayune, MS. Take Hwy. 43 to Walkiah Bluff Water Park or to Dumas Wise Road to access the Refuge.